the role of toll-like receptors in pain control
Authors
abstract
the toll like (family of receptors tlr) are expressed primarily by immune cells and are known to be part of innate immune system. in the past decade involvement of tlrs in several physiologic and pathologic pathways has been proved. pain transmission via glial activation is one of such interesting fields. both pathological pain states and treatment have also been shown to be related to tlr-related pathways. opioid agonists are found to possess tlr4 agonistic effects and glial activity. targeting tlrs could be a novel method for treatment of neuropathic pain. moreover attenuation of glial activation by the aim of selective tlr antagonistic drugs, may become a preferred way of separating the beneficial (analgesia) and unwanted effects of opioids, improving their safety and efficacy.
similar resources
The Role of Toll-Like Receptors in Breast Cancer
Breast cancer is highly prevalent worldwide. Treatment of this disease is a major global public health problem; therefore, numerous studies have explored new molecular profile helping for breast cancer therapy. Different risk factors are attributed to breast cancer; however, chronic inflammation and immune regulation are highly essential. Various molecules impact this context, including toll-li...
full textP-184: The Role of Cell Surface Toll Like Receptors in Endometriosis
Background: Toll like receptors (TLRs) are a major family of innate immune systems which recognize specific pathogen associated molecular patterns (PAMPS)in bacterial, fungi, virus and parasites. Human TLRs comprise a large family of 10 different type proteins that are expressed on various immune cells. Among these receptors, TLR1, 2, 4, 5, 6 and 10 were expressed on the cell surface. TLR2 form...
full textrole of toll-like receptors in tuberculosis infection
background one-third of the world’s population is infected with mycobacterium tuberculosis. investigation of toll-like receptors (tlrs) has revealed new information regarding the immunopathogenesis of this disease. toll-like receptors can recognize various ligands with a lipoprotein structure in the bacilli. toll-like receptor 2 and tlr-4 have been identified in association with tuberculosis in...
full textToll-like receptors control autophagy.
Autophagy is a newly recognized innate defense mechanism, acting as a cell-autonomous system for elimination of intracellular pathogens. The signals and signalling pathways inducing autophagy in response to pathogen invasion are presently not known. Here we show that autophagy is controlled by recognizing conserved pathogen-associated molecular patterns (PAMPs). We screened a PAMP library for e...
full textMy Resources
Save resource for easier access later
Journal title:
journal of cellular and molecular anesthesiaجلد ۲، شماره ۱، صفحات ۲۴-۲۹
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023